Home » Our Services » Functional studies
Functional studies
Phenotypic analysis
- Differential blood counts
- Histological analysis of spleen, lymph node, Peyer´s patches and thymus
- Serological analysis of antibody isotype distribution using ELISA
- Immunophenotyping: flow cytometric cell surface analysis of T and B lymphocytes, NK-cells und monocytes/macrophages
Functional studies in vitro
- Measurement of NK-activity ex vivo and following in vitro stimulation
- Antigen dependent T-cell proliferation assays
- Serological quantification of antibody concentrations
- Measurement of B cell activity using hemagglutination or hemolysis assays
- Phagocytosis or migration assays
Functional studies in vivo
- Measurement of DTH reactions
- Autoimmunity studies
- Tumorigenicity / oncogenicity
- Vaccine studies
- Potency assays / efficacy studies
Pharmacological in vitro studies
- Pharmacokinetics of biologicals (direct / biomarkers)*
- Anti-drug antibody assays (screening / confirmatory ADA)*
Immunohistological analytics
- Detection of specific antigens in selected tissues
- Fluorescence or enzyme-linked detection systems
- Semi-quantitative analysis and analytics of IHC
- Tissue cross-reactivity
in vivo analysis for adventitious viruses according to
- European Pharmacopoeia 2.6.16 (Ph.Eur.)
- ICH guideline Q5A (CPMP/ICH/295/95)
- Points to Consider PTC (1993)